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Thursday, September 23, 2021

Do the Experimental mRNA Pictures Have Unexpected Results?

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“Let’s begin with a thought experiment: If an engineering design flaw exists and nobody measures it, can it actually injure folks or kill them?” a Twitter consumer named Ehden writes.1 He goes on to debate an ignored side of the COVID mRNA photographs, one thing referred to as “codon optimization,” which just about ensures sudden outcomes. Ehden explains:2

“Making an attempt to inform your physique to generate proteins is tough for a lot of causes. Considered one of them is the truth that while you attempt to run the protein data through ribosomes which course of that code and generate the protein, it may be very gradual or can get caught in the course of the course of.

Fortunately, scientists discovered a option to overcome this drawback, by doing code substitution: as an alternative of utilizing the unique genetic code to generate the protein, they modified the letters within the code so the code can be optimized. This is named Codon Optimization.”

COVID Pictures Use Codon Optimization

A codon consists of three nucleotides, and nucleotides are the constructing blocks of DNA. An August 2021 article in Nature Critiques Drug Discovery, addressed the usage of codon optimization as follows:3

“The open studying body of the mRNA vaccine is essentially the most essential part as a result of it comprises the coding sequence that’s translated into protein.

Though the open studying body is just not as malleable because the non-coding areas, it may be optimized to extend translation with out altering the protein sequence by changing not often used codons with extra incessantly occurring codons that encode the identical amino acid residue.

As an example, the biopharmaceutical firm CureVac AG found that human mRNA codons not often have A or U on the third place and patented a technique that replaces A or U on the third place within the open studying body with G or C. CureVac used this optimization technique for its SARS-CoV-2 candidate CVnCoV …

Though substitute of uncommon codons is a pretty optimization technique, it should be used judiciously. It is because, within the case of some proteins, the slower translation fee of uncommon codons is critical for correct protein folding.

To maximise translation, the mRNA sequence usually incorporates modified nucleosides, equivalent to pseudouridine, N1-methylpseudouridine or different nucleoside analogues. As a result of all native mRNAs embrace modified nucleosides, the immune system has advanced to acknowledge unmodified single-stranded RNA, which is a trademark of viral an infection.

Particularly, unmodified mRNA is acknowledged by sample recognition receptors, equivalent to Toll-like receptor 3 (TLR3), TLR7 and TLR8, and the retinoic acid-inducible gene I (RIGI) receptor. TLR7 and TLR8 receptors bind to guanosine- or uridine-rich areas in mRNA and set off the manufacturing of kind I interferons, equivalent to IFNα, that may block mRNA translation.

Using modified nucleosides, notably modified uridine, prevents recognition by sample recognition receptors, enabling enough ranges of translation to supply prophylactic quantities of protein.

Each the Moderna and Pfizer–BioNTech SARS-CoV-2 vaccines … include nucleoside-modified mRNAs. One other technique to keep away from detection by sample recognition receptors, pioneered by CureVac, makes use of sequence engineering and codon optimization to deplete uridines by boosting the GC content material of the vaccine mRNA.”

A lot of this data was beforehand reviewed in my interview with Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D. You’ll be able to’t see the article however the video is embedded above. This examine was printed effectively after our interview and merely confirms what Seneff and Mikovits have unraveled of their analysis.

Based on Ehden, 60.9% of the codons in COVID photographs have been optimized, equal to 22.5% of the nucleotides, however he doesn’t specify which shot he’s speaking about, or precisely the place the info got here from.

That every one mRNA COVID photographs are utilizing codon optimization to at least one diploma or one other is evident, nevertheless. A July 2021 article4 within the journal Vaccines particularly evaluates and feedback on the Pfizer/BioNTech and Moderna mRNA photographs, noting:

“The design of Pfizer/BioNTech and Moderna mRNA vaccines includes many several types of optimizations … The mRNA parts of the vaccine have to have a 5′-UTR to load ribosomes effectively onto the mRNA for translation initiation, optimized codon utilization for environment friendly translation elongation, and optimum cease codon for environment friendly translation termination.

Each 5′-UTR and the downstream 3′-UTR must be optimized for mRNA stability. The substitute of uridine by N1-methylpseudourinine (Ψ) complicates a few of these optimization processes as a result of Ψ is extra versatile in wobbling than U. Completely different optimizations can battle with one another, and compromises would have to be made.

I spotlight the similarities and variations between Pfizer/BioNTech and Moderna mRNA vaccines and talk about the benefit and drawback of every to facilitate future vaccine enchancment. Specifically, I level out a couple of optimizations within the design of the 2 mRNA vaccines that haven’t been carried out correctly.”

What Can Go Fallacious?

One key take-home from the Nature Critiques Drug Discovery article5 cited above is that changing uncommon codons “should be used judiciously,” as rarer codons can have slower translation charges and a slowed-down fee is definitely vital to forestall protein misfolding.

A (adenine) and U (uracil) within the third place are uncommon, and the COVID photographs exchange these A’s and U’s with G’s (guanine) or C’s (cytosine). Based on Seneff, this change ends in a 1,000-fold larger quantity of spike protein in comparison with being contaminated with the precise virus.

What may go incorrect? Properly, absolutely anything. Once more, the shot induces spike protein at ranges unprecedented in nature (even when SARS-CoV-2 is a “souped up” artifical concoction), and the spike protein is the poisonous a part of the virus answerable for essentially the most distinctive results of the virus, such because the blood clotting issues, neurological issues and coronary heart harm.

So, to anticipate the COVID shot to not produce these sorts of results can be relatively naïve. The codon switches may additionally end in protein misfolding, which is equally unhealthy information. As defined by Seneff in our earlier interview:

“The spike proteins that these mRNA vaccines are producing … aren’t in a position to enter the membrane, which I feel goes to encourage it to change into a problematic prion protein. Then, when you’ve gotten irritation, it upregulates alpha-synuclein [a neuronal protein that regulates synaptic traffic and neurotransmitter release].

So, you are going to get alpha-synuclein drawn into misfolded spike proteins, turning into a multitude contained in the dendritic cells within the germinal facilities within the spleen. And they will package deal up all this crud into exosomes and launch them. They’re then going to journey alongside the vagus nerve to the brainstem and trigger issues like Parkinson’s illness.

So, I feel this can be a full setup for Parkinson’s illness … It may push ahead the date at which somebody who has a propensity in direction of Parkinson’s goes to get it.

And it is in all probability going to trigger folks to get Parkinson’s who by no means would have gotten it within the first place — particularly in the event that they hold getting the vaccine yearly. Yearly you do a booster, you carry the date that you’ll get Parkinson’s ever nearer.”

Immune Dysfunction and Viral Flare-Ups

Different important threats embrace immune dysfunction and the flare-up of latent viral infections, which is one thing Mikovits has been warning about. In our earlier interview, she famous:

“We use poly(I:C) [a toll-like receptor 3 agonist] to sign the cell to activate the sort I interferon pathway, and since [the spike protein your body produces in response to the COVID shot] is an unnatural artificial envelope, you are not seeing poly(I:C), and you are not [activating] the Sort I interferon pathway.

You have bypassed the plasmacytoid dendritic cell, which mixed with IL-10, by speaking to the regulatory B cells, decides what subclasses of antibodies to place out. So, you’ve got bypassed the communication between the innate and adaptive immune response. You now miss the signaling of the endocannabinoid receptors …

A big a part of Dr. [Francis] Ruscetti’s and my work during the last 30 years has been to point out you do not want an infectious transmissible virus — simply items and elements of those viruses are worse, as a result of additionally they activate hazard alerts. They act like hazard alerts and pathogen-associated molecular patterns.

So, it synergistically leaves that inflammatory cytokine signature on that spins your innate immune response uncontrolled. It simply can not sustain with the myelopoiesis [the production of cells in your bone marrow]. Therefore you see a skew-away from the mesenchymal stem cell in direction of TGF-beta regulated hematopoietic stem cells.

This implies you would see bleeding issues on each ends. You’ll be able to’t make sufficient firetrucks to ship to the fireplace. Your innate immune response cannot get there, and you then’ve simply acquired a complete practice wreck of your immune system.”

We’re now seeing experiences of herpes and shingles an infection following COVID-19 injection, and that is exactly what you’ll be able to anticipate in case your Sort I interferon pathway is disabled. That’s not the tip of your potential troubles, nevertheless, as these coinfections may speed up different ailments as effectively.

For instance, herpes viruses have been implicated as a set off of each AIDS6 and myalgic encephalomyelitis7 (power fatigue syndrome or ME-CFS). Based on Mikovits, these ailments don’t seem till viruses from completely different households accomplice up and retroviruses take out the Sort 1 interferon pathway. Long run, the COVID mass injection marketing campaign could also be laying the muse for a quickly approaching avalanche of a variety of debilitating power sicknesses.

Are COVID Pictures Appropriately Optimized?

As famous within the Vaccines article cited earlier, the codon optimization within the Pfizer and Moderna photographs may very well be problematic:8

“As mammalian host cells assault unmodified exogeneous RNA, all U nucleotides had been changed by N1-methylpseudouridine (Ψ). Nevertheless, Ψ wobbles extra in base-pairing than U and might pair not solely with A and G, but additionally, to a lesser extent, with C and U.

That is more likely to enhance misreading of a codon by a near-cognate tRNA. When nucleotide U in cease codons was changed by Ψ, the speed of misreading of a cease codon by a near-cognate tRNAs elevated.

Such readthrough occasions wouldn’t solely lower the variety of immunogenic proteins, but additionally produce an extended protein of unknown destiny with probably deleterious results …

The designers of each vaccines thought-about CGG because the optimum codon within the CGN codon household and recoded virtually all CGN codons to CGG … [M]ultiple traces of proof counsel that CGC is a greater codon than CGG. The designers of the mRNA vaccines (particularly mRNA-1273) selected a incorrect codon because the optimum codon.”

The paper additionally factors out the significance of vaccine mRNA to be translated precisely and never merely successfully, as a result of if the incorrect amino acids are integrated, it might probably confuse your immune system and forestall it from figuring out the proper targets.

Accuracy can be vital in translation termination, and right here it comes right down to choosing the proper cease codons. Cease codons (UAA, UAG or UGA), when current on the finish of an mRNA coding sequence alerts the termination of protein synthesis.

Based on the writer, each Pfizer and Moderna chosen lower than optimum cease codons. “UGA is a poor alternative of a cease codon, and UGAU in Pfizer/BioNTech and Moderna mRNA vaccines may very well be even worse,” she says.

What Well being Issues Can We Anticipate to See Extra Of?

Whereas the number of ailments we might even see an increase in on account of this vaccination marketing campaign are myriad, some basic predictions might be made. We’ve already seen an enormous uptick in blood clotting issues, coronary heart assaults and stroke, in addition to coronary heart irritation.

Extra long run, Seneff believes we’ll see a major rise in most cancers, accelerated Parkinson’s-like ailments, Huntington’s illness, and all forms of autoimmune ailments and neurodegenerative issues.

Mikovits additionally suspects many will develop power and debilitating ailments and can die prematurely. At highest danger, she locations those that are asymptomatically contaminated with XMRVs and gammaretroviruses from contaminated typical vaccines. The COVID shot will successfully speed up their demise by crippling their immune operate. “The youngsters which are extremely vaccinated, they’re ticking time bombs,” Mikovits stated in my Might 2021 interview. 

What Are the Choices?

Whereas all of that is extremely problematic, there may be hope. From my perspective, I imagine the perfect factor you are able to do is to construct your innate immune system. To do this, it’s essential change into metabolically versatile and optimize your weight loss plan. You’ll additionally need to be certain that your vitamin D stage is optimized to between 60 ng/mL and 80 ng/mL (100 nmol/L to 150 nmol/L).

I additionally suggest time-restricted consuming, the place you eat all of your meals for the day inside a six- to eight-hour window. Time-restricted consuming may even upregulate autophagy, which can assist digest and take away spike protein. Keep away from all vegetable oils and processed meals. Deal with certified-organic meals to reduce your glyphosate publicity.

Sauna remedy can also be useful. It upregulates warmth shock proteins, which may help refold misfolded proteins. In addition they tag broken proteins and goal them for elimination.

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